Chapter

Solving the phase problem using isomorphous replacement

Sherin S. Abdel-Meguid

in Macromolecular Crystallography

Published in print August 2007 | ISBN: 9780198520979
Published online September 2007 | e-ISBN: 9780191706295 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780198520979.003.0006
 Solving the phase problem using isomorphous replacement

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This chapter begins with a discussion of the theoretical basis of isomorphous replacement. It then discusses the selection of heavy-atom reagents, heavy atoms and their ligands, preparation of heavy-atom derivatives, determination of heavy-atom positions, and refinement of heavy-atom positions.

Keywords: isomorphous replacement; heavy atoms; crystallography; ligands; heavy-atom position

Chapter.  5013 words.  Illustrated.

Subjects: Biochemistry

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