Chapter

Functional morphology of CTA

T. Yamamoto

in Conditioned Taste Aversion

Published in print May 1998 | ISBN: 9780198523475
Published online January 2008 | e-ISBN: 9780191712678 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780198523475.003.0007

Series: Oxford Psychology Series

 Functional morphology of CTA

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CTA formation is indicated by increased c-fos activity in AP, NTS, Am, and HPV neurons. Palatable taste and hedonically positive values trigger c-fos responses in the medial PBN, aversive taste, and hedonically negative values in the lateral PBN. Although increased c-fos expression was observed in PBN of CTA trained rats even after ablation of IC, Am, and VM, it was not accompanied by rejection of saccharin which was blocked by precollicular decerebration at the level interrupting the descending influence of cortical and diencephalic centers. Increased c-fos synthesis appears also in the ventromedial NTS in the CTA trained rats receiving sucrose as the CS. Intracellular cascades implementing CTA learning are documented by the blocking effect of anisomycin injected into the IC immediately before CS administration. Protein kinase C (PKC) activation reaches maximum 24–48h after saccharin-LiCl pairing and declines after 120h. Injection of PKC inhibitor polymyxin B or H7 into IC or AM blocks CTA acquisition.

Keywords: c-fos activity; hedonically positive; medial PBN; hedonically negative; lateral PBN; precollicular decerebration; ventromedial NTS; anisomycin; protein kinase C; polymyxin B

Chapter.  6135 words.  Illustrated.

Subjects: Neuropsychology

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