Chapter

Sialic acids in gangliosides: origin and function

Guido Kohla and Roland Schauer

in Neuroglycobiology

Published in print July 2005 | ISBN: 9780198525387
Published online September 2009 | e-ISBN: 9780191723872 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780198525387.003.0006

Series: Molecular and Cellular Neurobiology Series

Sialic acids in gangliosides: origin and function

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Eukaryotic cells are composed of numerous lipids, among which the glycosphingolipids and especially the sialic-acid-containing gangliosides occur ubiquitously in most tissues. They are particularly common in neuroectodermal cells where they comprise up to 6% of the total lipids in central and peripheral nervous tissue membranes. This chapter focuses on the various sialic acid modifications which occur in gangliosides, especially those from neuronal tissues, and which may modulate their biological effect. It describes the structures of the various natural sialic acids and their general metabolic pathway and its subcellular localization. It shows the biosynthesis of the various sialic acids with respect to the modified gangliosides.

Keywords: sialic acids; gangliosides; metabolism; sulfated sialic acids; lipids; biological effect

Chapter.  9721 words.  Illustrated.

Subjects: Neuroscience

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