Chapter

From associations to expectancies: orbitofrontal cortex as gateway between the limbic system and representational memory

Matthew Roesch and Geoffrey Schoenbaum

in The Orbitofrontal Cortex

Published in print October 2006 | ISBN: 9780198565741
Published online February 2010 | e-ISBN: 9780191723971 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780198565741.003.0008
From associations to expectancies: orbitofrontal cortex as gateway between the limbic system and representational memory

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This chapter describes the role of the rodent orbitofrontal cortex (OFC) in the control of associative information and its application to govern behavior. Recent findings support a critical role for OFC in affective processing as part of a circuit that includes the amygdala and other limbic structures. It is argued that the OFC allows associative information, particularly information about the value of likely outcomes, to be manipulated in representational memory and integrated with non-associative variables concerning subsequent behavior, current context and internal state. The resultant ‘expectancies’ then influence processing in downstream limbic areas as well as other prefrontal regions, thereby promoting voluntary, cognitive, and goal-directed behavior and facilitating new learning.

Keywords: amygdala; rodent; reward; expectancy; association; learning; lesion; neurophysiology

Chapter.  17886 words.  Illustrated.

Subjects: Neuroscience

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