Preview
As most amino acid substitutions are not related to the functional divergence but only represent the neutral evolution, it becomes crucial how to distinguish statistically between these two possibilities. Chapter 3 introduced the statistical methods to solve this problem, based on the principle that functional divergence between duplicate genes is highly correlated with the change of evolutionary rate. This chapter discusses several case studies for applying these methods to biological problems.
Keywords: gene duplication; functional divergence; case studies; amino acid substituion
Chapter. 6985 words. Illustrated.
Subjects: biomathematics
Go to Oxford Scholarship Online » abstract
full text: subscription required