Chapter

Near‐Field Optical And Plasmonic Imaging

Yuan Wang and Xiang Zhang

in Micro/Nano Technology Systems for Biomedical Applications

Published in print March 2010 | ISBN: 9780199219698
Published online September 2010 | e-ISBN: 9780191594229 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199219698.003.0008
Near‐Field Optical And Plasmonic Imaging

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This chapter reviews the recent development of near-field biomolecule imaging systems. Near-field scanning optical microscopy (NSOM) offers a practical means of optical imaging at a resolution well beyond the diffraction limit of light. Applications are limited, however, due to strong attenuation of transmitted light through the sub-wavelength aperture. A variety of approaches to address this problem, such as apertureless NSOM and plasmonic near-field focusing devices, are covered in this chapter. These approaches provide an enhanced nanoscale imaging tool for cellular visualization, single molecule detection, and many other applications requiring high spatial and temporal resolution.

Keywords: biomolecule imaging; high resolution; sub-wavelength; diffraction limit; NSOM; near-field; plasmonic

Chapter.  7048 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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