Tza‐Huei Wang, Kelvin Liu, Hsin‐Chih Yeh and Christopher M. Puleo

in Micro/Nano Technology Systems for Biomedical Applications

Published in print March 2010 | ISBN: 9780199219698
Published online September 2010 | e-ISBN: 9780191594229 | DOI:

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This chapter discusses and provides insight into state of the art nanobiosensors used in high sensitivity molecular analysis and detection. It begins with an introduction into the fundamental considerations of nanobiosensor design. To date, a myriad of sensors has been developed based on a wide array of nanomaterials using both optical and electrical signal transduction methods. Illustrative examples of various nanobiosensors based on metallic nanoparticles, semiconductor nanocrystals, and nanowire/nanotubes are given and organized according to the specific signal transduction mechanisms employed. Finally, single molecule detection methods are discussed as techniques to accurately analyze and quantify the output signal of fluorescent nanobiosensors. The chapter concludes with a brief prospective into the future of nanomaterials based sensing systems.

Keywords: nanobiosensors; metallic nanoparticles; semiconductor nanocrystals; quantum dots; nanowires; nanotubes; confocal fluorescence spectroscopy; single molecule detection

Chapter.  17972 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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