Chapter

Surface Molecular Property Control

Robin L. Garrell and Heather D. Maynard

in Micro/Nano Technology Systems for Biomedical Applications

Published in print March 2010 | ISBN: 9780199219698
Published online September 2010 | e-ISBN: 9780191594229 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199219698.003.0011
Surface Molecular Property Control

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Current technologies to modify surfaces and control the surface properties are reviewed, with particular emphasis on alterations for biomedical and bioanalytical applications. A brief tutorial on the mechanisms of biomolecular adsorption provides background for understanding the relationship between surface wettability and biomolecular (particularly protein) adsorption. Methods for modifying surface wettability, materials that minimize or prevent fouling, and techniques for assessing protein fouling and the effectiveness of surface modifications are reviewed. Examples of “designer surfaces” are given, ranging from dynamic coatings in which small molecules or polymers are adsorbed on device surfaces, to covalent modifications such as PEGylation, hydrogel assembly, and the use of functionalized alkyl silanes. New device materials, including hydrogels made from PEGylated monomers, biodegradable polyesters, and photocurable perfluoropolyethers, are also discussed. The chapter closes with approaches that lead to the direct and indirect capture of proteins and peptides and the integration of live cells with microfluidic devices.

Keywords: wettability; protein adsorption; covalent modifications; polymer; hydrogel; cells; dynamic coatings; PEGylation; alkyl silanes; devices

Chapter.  14165 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology

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