The OPTIMA Cohort

Mark Holodniy

in A Decade of HAART

Published in print August 2008 | ISBN: 9780199225859
Published online September 2009 | e-ISBN: 9780191723834 | DOI:
The OPTIMA Cohort

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This chapter reviews the Options in Management with Antiretrovirals (OPTIMA) study. OPTIMA study is the first tri-national collaboration between the US Department of Veterans Affairs (VA), Canadian Institutes for Health Research, and the UK Medical Research Council. It is a prospective, randomized, 2-factorial design study looking at the clinical utility of a three-month antiretroviral drug-free period (ARDFP), and whether there is a difference in effectiveness between standard and ‘mega-regimens’ (five or more active antiretroviral drugs).

Keywords: highly active antiretroviral therapy; cohort study; Options in Management with Antiretrovirals; HIV/AIDS research

Chapter.  8212 words.  Illustrated.

Subjects: Public Health and Epidemiology

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