Chapter

The clinical challenges of lifetime HAART

Roger Paredes, Renslow Sherer and Bonaventura Clotet

in A Decade of HAART

Published in print August 2008 | ISBN: 9780199225859
Published online September 2009 | e-ISBN: 9780191723834 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199225859.003.0026
The clinical challenges of lifetime HAART

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This chapter summarizes the principal challenges of antiretroviral therapy (ART) in both resource-rich and developing world settings as of the end of year 2006 and discusses the options available to address them. It shows that long-term ART involves problems of adherence, resistance and toxicity as well as cost. It also shows how the successes of HAART have modified the clinical presentation of cancers in HIV-infected individuals and how the aging of HIV-positive patients is gradually increasing the development of geriatric syndromes that were rarely seen just a few years ago. Early detection and aggressive management of hepatitis co-infections are needed in order to avoid the severe complications and elevated mortality of end-stage liver disease.

Keywords: highly active antiretroviral therapy; HIV/AIDS; treatment; long-term ART

Chapter.  23200 words.  Illustrated.

Subjects: Public Health and Epidemiology

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