Chapter

Comparative genomics of insect immunity

Fotis Kafatos, Robert Waterhouse, Evgeny Zdobnov and George Christophides

in Insect Infection and Immunity

Published in print June 2009 | ISBN: 9780199551354
Published online September 2009 | e-ISBN: 9780191720505 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199551354.003.0006
Comparative genomics of insect immunity

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This chapter compares the Drosophila group with mosquitoes and honeybees to disentangle common themes from specific components of immunity. Honeybees, for example, have a relatively small set of immune genes which demonstrate a high degree of conservatism. They are most intriguing when compared with non-social insects, as the differences between them are attributable to the evolution of sociality in bees and other Hymenoptera. The chapter highlights how the use of comparative genomics led to the unravelling of evolutionary novelties. Genes containing leucine-rich repeats are an example, which led to the discovery of a new complement-like mechanism in mosquitoes.

Keywords: insect immunity; immune response; Drosophila; mosquitoes; honeybees

Chapter.  10619 words.  Illustrated.

Subjects: Evolutionary Biology

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