Physiological integration of innate immunity

David Schneider

in Insect Infection and Immunity

Published in print June 2009 | ISBN: 9780199551354
Published online September 2009 | e-ISBN: 9780191720505 | DOI:
Physiological integration of innate immunity

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Understanding how insect immunity is regulated requires studying the interactions of all those aspects of physiology that impact immunity. This includes both resistance and tolerance aspects of defence as well as all of the other assorted physiological systems of the insect that alter the immune response. It is hypothesized that an insect's innate immune responses is in the centre of a physiological net and the immune response is sensitive to changes throughout this net. This chapter tries to tie all of these physiological strands together and demonstrate how innate immunity alters the gross physiology of an insect and how the gross physiology, in turn, alters the immune response. An emergent property that falls out of this analysis is the prediction of several types of physiological collapse — these collapses result from positive-feedback loops that lead to amplified and damage-inducing immune/physiological responses.

Keywords: insect immunity; immune response; innate immunity; gross physiology

Chapter.  7720 words.  Illustrated.

Subjects: Evolutionary Biology

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