Imaging the Hippocampus

Bradford C. Dickerson and Jean C. Augustinack

in The Clinical Neurobiology of the Hippocampus

Published in print July 2012 | ISBN: 9780199592388
Published online September 2012 | e-ISBN: 9780199949922 | DOI:
Imaging the Hippocampus

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An extensive body of literature has accrued on the imaging of the human hippocampus since it was first visualized clearly in a living person using magnetic resonance imaging (MRI) in the late 1980s. Clinicians now routinely perform high-resolution MRI to inspect the structure of the hippocampus and surrounding cortices in detail in patients suspected of having Alzheimer’s disease (AD) and related disorders, temporal lobe epilepsy and related conditions, or limbic encephalitis, transient global amnesia, or other forms of amnesia. Researchers have developed protocols for measuring the size of the hippocampus and are now working toward visualization and measurement of hippocampus subfields in vivo. Investigators are also using advanced imaging techniques to measure hippocampal activity during memory and other tasks as well as its perfusion, metabolism, and molecular constituents. New technical advances in imaging continue to be applied to the investigation of the hippocampus, medial temporal cortices, and connected brain regions, and will certainly lead to novel clinical insights that should improve patient care.

Keywords: magnetic resonance imaging; functional MRI; volumetric analysis; neuroanatomy

Chapter.  16998 words.  Illustrated.

Subjects: Neuroscience

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