Temporal Lobe Epilepsy and the Hippocampus

Radwa A.B. Badawy and Graeme D. Jackson

in The Clinical Neurobiology of the Hippocampus

Published in print July 2012 | ISBN: 9780199592388
Published online September 2012 | e-ISBN: 9780199949922 | DOI:
Temporal Lobe Epilepsy and the Hippocampus

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Hippocampal sclerosis (HS) is the commonest cause of temporal lobe epilepsy which accounts for 3–50% of all epilepsy syndromes. This chapter reviews the pathological substrate of HS and mesial temporal sclerosis and how this relates to epileptogenesis and seizures. It then discusses the clinical picture of different forms of temporal lobe epilepsy and common findings on electroencephalography and imaging. Invasive and non-invasive diagnostic tools assessing epileptogenicity of the hippocampus are reviewed. Finally, the chapter presents an overview of management options available for patients with temporal lobe epilepsy.

Keywords: medial and lateral temporal lobe epilepsy; mesial temporal sclerosis; hippocampal sclerosis focal seizures; convulsive seizures; loss of awareness; electroencephalography; magnetic resonance imaging; functional imaging treatment of temporal lobe epilepsy

Chapter.  12403 words.  Illustrated.

Subjects: Neuroscience

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