Chapter

The Hippocampus and Post-Traumatic Disorders

J. Douglas Bremner and Eric Vermetten

in The Clinical Neurobiology of the Hippocampus

Published in print July 2012 | ISBN: 9780199592388
Published online September 2012 | e-ISBN: 9780199949922 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199592388.003.0014
The Hippocampus and Post-Traumatic Disorders

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The hippocampus plays an important role in post-traumatic mental disorders. Alterations in the hippocampus have been shown in patients with a number of stress-related mental disorders, including post-traumatic stress disorder, borderline personality disorder, depression related to early abuse, and dissociative identity disorder. The hippocampus interacts with other brain regions, including the amygdala and prefrontal cortex, to mediate the stress response. Neuroimaging studies in patients with trauma-related mental disorders have replicated findings in animal studies by finding alterations in hippocampal function and structure. Abnormalities in the hippocampus are hypothesized to underlie, at least in part, symptoms of trauma-related psychiatric disorders. Psychotherapeutic interventions need to target the hippocampal circuit in order to maximize therapeutic effects. These can be found in medical interventions (e.g. selective serotonin reuptake inhibitors) as well as in psychotherapeutic interventions.

Keywords: depression; positron emission tomography; stress; post-traumatic stress disorder

Chapter.  9042 words.  Illustrated.

Subjects: Neuroscience

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