Chapter

The somatic tinnitus model

Jos J. Eggermont

in The Neuroscience of Tinnitus

Published in print May 2012 | ISBN: 9780199605606
Published online September 2012 | e-ISBN: 9780191741555 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199605606.003.0008
The somatic tinnitus model

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Inputs from the trigeminal and dorsal column systems innervate the granule cells in the dorsal cochlear nucleus. The output of the granule cells activates both excitatory neurons such as the fusiform and giant cells, as well as the cartwheel cells, which inhibit the fusiform cells and may also excite or inhibit other cartwheel cells. The resulting effect is a modulation of auditory inputs to the fusiform cells; this can be excitatory, inhibitory as well as a temporally offset combination thereof. This underlies the modulation of tinnitus loudness by, e.g., jaw movements and gaze changes. Following hearing loss, the strength of the synapses of the somatosensory inputs increases and the activation thresholds decrease. This has been linked to increased spontaneous firing rates and consequently to tinnitus.

Keywords: brain imaging; trigeminal ganglion; cochlear nucleus; inferior colliculus; dorsal column nuclei; vesicular glutamate transporters; multi-modal interaction

Chapter.  5166 words.  Illustrated.

Subjects: Neuroscience

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