Chapter

Mechanics of tumor growth: Multiphase models, adhesion, and evolving configurations

Luigi Preziosi and Guido Vitale

in New Trends in the Physics and Mechanics of Biological Systems

Published in print May 2011 | ISBN: 9780199605835
Published online September 2011 | e-ISBN: 9780191729522 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199605835.003.0007

Series: Lecture Notes of the Les Houches Summer School

Mechanics of tumor growth: Multiphase models, adhesion, and evolving configurations

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This chapter provides the basics to deduce multiphase models for the essential constituents present in tumours (cells, extracellular matrix, extracellular liquid, and possibly blood and limphatic vasculature). All the steps of the modelling procedure are explained in detail, special attention being paid to the meaning of all the different terms involved in the model. The chapter focuses on several mechanical aspects related to tumour growth, e.g., the activation of mechanotransduction pathways inside the cell, contact inhibition phenomena, the formation of stiffer fibrotic tissues, the adhesion phenomena characterizing the mechanical interaction between cells and between cell and extracellular matrix, and cell re-organization within the tissue.

Keywords: multiphase models; biomechanics; adhesion; remodelling; fibrosis; mechanotransduction; contact inhibition; tumour growth; cancer modelling

Chapter.  19591 words.  Illustrated.

Subjects: Physics

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