Chapter

Nonparametric Bayesian Networks*

Katja Ickstadt, Bjöorn Bornkamp, Marco Grzegorczyk, Jakob Wieczorek, Malik R. Sheriff, Hernáan E. Grecco and Eli Zamir

in Bayesian Statistics 9

Published in print October 2011 | ISBN: 9780199694587
Published online January 2012 | e-ISBN: 9780191731921 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199694587.003.0010
Nonparametric Bayesian Networks*

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A convenient way of modelling complex interactions is by employing graphs or networks which correspond to conditional independence structures in an underlying statistical model. One main class of models in this regard are Bayesian networks, which have the drawback of making parametric assumptions. Bayesian nonparametric mixture models offer a possibility to overcome this limitation, but have hardly been used in combination with networks. This manuscript bridges this gap by introducing nonparametric Bayesian network models. We review (parametric) Bayesian networks, in particular Gaussian Bayesian networks, from a Bayesian perspective as well as nonparametric Bayesian mixture models. Afterwards these two modelling approaches are combined into nonparametric Bayesian networks. The new models are compared both to Gaussian Bayesian networks and to mixture models in a simulation study, where it turns out that the nonparametric network models perform favourably in non‐Gaussian situations. The new models are also applied to an example from systems biology, namely finding modules within the MAPK cascade.

Keywords: Gaussian Bayesian networks; Systems Biology; Nonparametric Mixture Models; Species Sampling Models

Chapter.  18260 words.  Illustrated.

Subjects: Probability and Statistics

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