Curtis L. Meinert

in An Insider’s Guide to Clinical Trials

Published in print May 2011 | ISBN: 9780199742967
Published online September 2011 | e-ISBN: 9780199897278 | DOI:

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This introductory chapter begins with a brief description of the origins of the term clinical trial and the concept of randomization. It then details the development of modern-day clinical trials, pioneered by Sir Austin Bradford Hill. His 1962 book Statistical Methods in Clinical and Preventive Medicine represented an important milestone in the field of clinical trials. This is followed by a discussion of single- vs. multicenter clinical trial and the classification of trials by design.

Keywords: clinical trials; randomization; Austin Bradford Hill; classification

Chapter.  3329 words. 

Subjects: Medical Statistics and Methodology

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