Chapter

Meta-analyses and Systematic Reviews

Curtis L. Meinert

in An Insider’s Guide to Clinical Trials

Published in print May 2011 | ISBN: 9780199742967
Published online September 2011 | e-ISBN: 9780199897278 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199742967.003.0018
Meta-analyses and Systematic Reviews

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A meta-analysis is an analysis using either aggregate results or individual patient data from published trials. It is done to provide a more comprehensive and informative view of results than is possible with any single trial. A related activity is systematic review. Such reviews, as applied to trials, typically involve efforts to identify all trials relevant to the question of interest, whether published or not, critical appraisals of the trials, and ultimately, a conclusion as to the weight of evidence for or against the treatment. Such reviews may or may not involve formal meta-analyses. Most meta-analyses, in contrast with systematic reviews, are based exclusively on published trials.

Keywords: clinical trial; meta-analysis; systematic review; published trials; critical appraisals

Chapter.  1828 words.  Illustrated.

Subjects: Medical Statistics and Methodology

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