Chapter

Criteria for Biological Interventions for Spinal Cord Injury Repair

Keith Tansey and Byron A Kakulas

in Restorative Neurology of Spinal Cord Injury

Published in print December 2011 | ISBN: 9780199746507
Published online January 2012 | e-ISBN: 9780199918768 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199746507.003.0007
Criteria for Biological Interventions for Spinal Cord Injury Repair

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This chapter reviews the pathophysiological status of the spinal cord after injury and establishes criteria for biological intervention. It details the pathological cascade that occurs during the acute phase of the injury in which damaged axons swell, excitatory neurotransmitters trigger excitotoxic injury, reactive oxygen species are generated, and inflammation develops, leading to further loss of neurons and glia. It describes the application of agents to impede this cascade and reduce the damage expressed in the finally established lesion. The chapter also reviews the effectiveness of pharmacological agents and neuronal grafts, and provides guidelines for what should be done for a patient with chronic post-traumatic spinal cord injury if neurobiological interventions are available.

Keywords: pathophysiological status; pathological cascade; axon damage; excitotoxic injury; reactive oxygen species; inflammation; neuronal grafts; chronic post-traumatic spinal cord injury

Chapter.  4850 words.  Illustrated.

Subjects: Neuroscience

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