Chapter

Vitamin A and Lung Cancer

Walter Willett and Graham Colditz

in Nutritional Epidemiology

Third edition

Published in print November 2012 | ISBN: 9780199754038
Published online January 2013 | e-ISBN: 9780199979448 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199754038.003.0017

Series: Monographs in Epidemiology and Biostatistics

Vitamin A and Lung Cancer

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Vitamin A has long been recognized to play a central physiologic role in the regulation of cell differentiation. Because loss of differentiation is a basic feature of malignancy, vitamin A may be related to cancer incidence. In numerous animal studies, naturally occurring preformed vitamin A and synthetic analogs have inhibited the occurrence of induced tumors and even reversed metaplastic changes. This chapter describes the unfolding of evidence on vitamin A and lung cancer, both because of the potential importance of the hypothesis and what it has taught us about nutritional epidemiology. Even today, the story is taking another twist with the potential integration of genetic and dietary data on this topic.

Keywords: cancer prevention; lung cancer; vitamin A; nutritional epidemiology

Chapter.  10111 words.  Illustrated.

Subjects: Medical Statistics and Methodology

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