Chapter

The Aromatization Hypothesis and the Discovery of Estrogen Synthesis by Brain Cells

Frederick Naftolin

in Brain Aromatase, Estrogens, and Behavior

Published in print October 2012 | ISBN: 9780199841196
Published online January 2013 | e-ISBN: 9780199979837 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199841196.003.0001

Series: Oxford Series in Behavioral Neuroendocrinology

The Aromatization Hypothesis and the Discovery of Estrogen Synthesis by Brain Cells

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Although the discovery that brain cells could make estrogen from androgen precursors derived from the need to understand the basis of brain sexual differentiation, the consequences of this observation have been far reaching in the fields of neurobiology and endocrinology. An historical account of the events leading up to the discovery and insights to the involved people are presented. As with many scientific observations, more questions were raised than were answered by proof of the “Aromatization Hypothesis.” However, knowing that this metabolism exists has opened the possibility of further progress in brain research and allied fields.

Keywords: brain sexual differentiation; estrogen; estrogen synthetase; hormone; synaptic plasticity

Chapter.  3638 words. 

Subjects: Neuroscience

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