Chapter

Regional Distribution of Aromatase in the Human Brain

Anat Biegon, Joanna Fowler, Sunny Kim, Jean Logan, Deborah Pareto and Gene-Jack Wang

in Brain Aromatase, Estrogens, and Behavior

Published in print October 2012 | ISBN: 9780199841196
Published online January 2013 | e-ISBN: 9780199979837 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199841196.003.0005

Series: Oxford Series in Behavioral Neuroendocrinology

Regional Distribution of Aromatase in the Human Brain

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Aromatase catalyzes the last step in the biosynthesis of estrogens in humans as well as in other species. The regional distribution and cellular and subcellular expression of human brain aromatase have been studied using different complementary methodologies, including in vivo positron emission tomography, immunohistochemistry, polymerase chain reaction (PCR), and enzyme activity assays. The regional and cellular distribution of human brain aromatase have some unique features compared with other primate and nonprimate species, including high levels in thalamus and more ubiquitous distribution among different cell types. These differences may underlie the involvement of estrogen in a range of nonreproductive behaviors and functions unique to humans.

Keywords: aromatase; CYP19A1; human brain; PET

Chapter.  4620 words.  Illustrated.

Subjects: Neuroscience

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