Chapter

Molecular Mechanisms Controlling Brain Aromatase Expression

Nobuhiro Harada and Shin-ichiro Honda

in Brain Aromatase, Estrogens, and Behavior

Published in print October 2012 | ISBN: 9780199841196
Published online January 2013 | e-ISBN: 9780199979837 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199841196.003.0008

Series: Oxford Series in Behavioral Neuroendocrinology

Molecular Mechanisms Controlling Brain Aromatase Expression

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Aromatase is expressed not only in gonadal tissues but also in nongonadal tissues including the brain, and participates in various tissue-specific functions through local production of estrogens. To control diverse physiological functions in various tissues, aromatase has a unique gene structure with multiple exons 1 and promoters that are used in a tissue-specific manner. The transcriptional regulation of aromatase expression is mediated by binding of tissue-specific transcription factors or hormones to their responsive elements on each promoter to activate or repress the transcriptional machinery. Possible regulatory factors/hormones, transcription factors, and DNA responsive elements involved in the tissue-specific expression of aromatase are reviewed in this chapter.

Keywords: alternative splicing; DNase footprinting; gel shift assay; hypothalamus; multiple exon 1 variants; perinatal period; promoter activity; responsive element; tissue-specific expression; transcription factor

Chapter.  6729 words.  Illustrated.

Subjects: Neuroscience

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