A Historical and Personal Perspective on the Aromatization Revolution: Steinach Confirmed<sup>1</sup>

Per Södersten

in Brain Aromatase, Estrogens, and Behavior

Published in print October 2012 | ISBN: 9780199841196
Published online January 2013 | e-ISBN: 9780199979837 | DOI:

Series: Oxford Series in Behavioral Neuroendocrinology

A Historical and Personal Perspective on the Aromatization Revolution: Steinach Confirmed1

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About a hundred years ago, transplantation of gonads to hosts of the opposite sex was reported to cause behavioral sex reversal and when synthetic androgens and estrogens became available somewhat later, treatment with estradiol was found to activate all aspects of sexual receptivity in adult castrated male rats. At the same time, it was suggested that estradiol synergizes with androgens in the brain to activate ejaculation in castrated male rats, and evidence was presented that male rats convert androgens to estrogen. Many of these effects have been confirmed recently, but no attempts have been made to confirm the remarkable demonstration, more than half a century ago, that adult castrated male rats can maintain normal cyclic ovarian function. History is more than enjoyable reading, it is essential reading to avoid making mistakes already made and avoid inventing the wheel more than once.

Keywords: gonadal hormones; gonadal transplantation; history; sexual behavior; sex differences; sex similarities

Chapter.  15562 words.  Illustrated.

Subjects: Neuroscience

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