Brain Aromatase and Neuroprotection in Mammals

Iñigo Azcoitia, Maria Angeles Arevalo and Luis Miguel Garcia-Segura

in Brain Aromatase, Estrogens, and Behavior

Published in print October 2012 | ISBN: 9780199841196
Published online January 2013 | e-ISBN: 9780199979837 | DOI:

Series: Oxford Series in Behavioral Neuroendocrinology

Brain Aromatase and Neuroprotection in Mammals

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Recent studies suggest that, at least under neurodegenerative conditions, local brain formation of estradiol by the enzyme aromatase is an endogenous neuroprotective mechanism. This chapter reviews neuroprotective actions of aromatase and local estradiol synthesis in different experimental models of brain pathology in mammals. The cell types involved in the production of aromatase after brain injury, the role of neurogenesis and synaptic plasticity in the mechanisms of neuroprotection, the consequences of aromatase deficiency for brain function, and the possible implication of brain aromatase in the generation of sex differences in brain pathology are also discussed.

Keywords: Alzheimer’s disease; brain injury; cerebellar ataxia; chronic hypertension; estradiol; neurodegeneration; neurogenesis; Parkinson’s disease; stroke; synaptic plasticity

Chapter.  5260 words.  Illustrated.

Subjects: Neuroscience

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