Chapter

Acute Synthesis and Action of Estrogens in Communication Circuits

Luke Remage-Healey

in Brain Aromatase, Estrogens, and Behavior

Published in print October 2012 | ISBN: 9780199841196
Published online January 2013 | e-ISBN: 9780199979837 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780199841196.003.0025

Series: Oxford Series in Behavioral Neuroendocrinology

Acute Synthesis and Action of Estrogens in Communication Circuits

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This chapter explores recent evidence that estrogen production and action within acoustic communication circuits occurs rapidly, at the time scale of neuromodulation (seconds to minutes). The chapter traces historical roots of this relatively new idea, and summarizes insights from comparative studies of vocalizing fish and avian species, which have revealed two concepts: (1) estrogens can be produced locally within brain circuits independent of levels elsewhere in the brain and the circulation, and (2) estrogens can have rapid effects within brain circuits to modulate social communication behaviors and sensory processing. Primary breakthroughs are presented, which shift the focus of the production and action of estrogens on exceedingly local and rapid events within the brain itself, as revealed through studies of neural circuits that govern social communication. This new perspective could be broadly informative among vertebrates, given the wide range of brain regions that exhibit aromatase expression and activity.

Keywords: acoustic; electrophysiology; microdialysis; neuromodulation; neurosteroids; nongenomic; speech

Chapter.  10909 words.  Illustrated.

Subjects: Neuroscience

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