Chapter

Developmental origins of astrocytes

James E. Goldman

in Glial Cell Development

Published in print November 1997 | ISBN: 9781872748542
Published online March 2012 | e-ISBN: 9780191724367 | DOI: http://dx.doi.org/10.1093/acprof:oso/9781872748542.003.0002

Series: The Molecular and Cellular Neurobiology Series

Developmental origins of astrocytes

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Our knowledge of specific molecular and physiological characteristics of astrocytes has increased tremendously in recent years. This chapter focuses on the origins of astrocytes and the lineage relationships of astrocytes to other neuroectodermal cells. A number of studies suggest two major pathways for astrocyte development. In one, astrocytes develop from precursor cells that originate in the ventricular and subventricular germinal zones as the cells migrate throughout the central nervous system. In the other, astrocytes differentiate from radial glia, themselves established earlier in development around the time of neurogenesis and neuronal migration.

Keywords: astrocyte development; neuroectodermal cells; ventricular zones; subventricular germinal zones; central nervous system; radial glia; neurogenesis

Chapter.  8974 words.  Illustrated.

Subjects: Neuroscience

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