Chapter

Axonal control of oligodendrocyte development

B.A. Barres and M.C. Raff

in Glial Cell Development

Published in print November 1997 | ISBN: 9781872748542
Published online March 2012 | e-ISBN: 9780191724367 | DOI: http://dx.doi.org/10.1093/acprof:oso/9781872748542.003.0004

Series: The Molecular and Cellular Neurobiology Series

Axonal control of oligodendrocyte development

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The only known function of oligodendrocytes is to myelinate axons in the vertebrate central nervous system (CNS). This chapter considers how the number of oligodendrocytes is matched during development to the number and length of axons requiring myelination. It reviews some recent evidence that axonal signals regulate the proliferation of oligodendrocyte precursor cells and the survival of oligodendrocytes in vivo. It remains unclear whether axons also regulate the migration and differentiation of developing oligodendrocytes in vivo, although this seems likely.

Keywords: oligodendrocyte precursors; central nervous system; myelin; axons; myelination

Chapter.  5732 words.  Illustrated.

Subjects: Neuroscience

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