Microglia in the developing and mature central nervous system

V. Hugh Perry

in Glial Cell Development

Published in print November 1997 | ISBN: 9781872748542
Published online March 2012 | e-ISBN: 9780191724367 | DOI:

Series: The Molecular and Cellular Neurobiology Series

Microglia in the developing and mature central nervous system

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This chapter shows that macrophages play a part in the removal of cellular debris from the developing central nervous system (CNS) and then differentiate to become microglia, the resident macrophages of the adult CNS. It is not yet known whether abnormal CNS function could result from aberrant or ineffective clearance of the developmentally generated debris. The downregulated phenotype of microglia, the unusual nature of the inflammatory response in the CNS, and the involvement of microglia in many neuropathologies indicates that there is still much to be learnt about the mononuclear phagocytes and their interactions with the CNS microenvironment.

Keywords: macrophages; CNS; cellular debris; microglia

Chapter.  7519 words.  Illustrated.

Subjects: Neuroscience

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