Chapter

The role of astrocytes in axon guidance during development and repair

Haila Vickland and Jerry Silver

in Glial Cell Development

Published in print November 1997 | ISBN: 9781872748542
Published online March 2012 | e-ISBN: 9780191724367 | DOI: http://dx.doi.org/10.1093/acprof:oso/9781872748542.003.0010

Series: The Molecular and Cellular Neurobiology Series

The role of astrocytes in axon guidance during development and repair

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Axon guidance depends on a combination of factors, including tissue architecture and supporting and inhibitory molecules that act locally to direct growth. This chapter presents some of the evidence for astrocyte involvement in this guidance and reviews knowledge of some of the molecules directly involved. The discussion covers astrocyte function during development, inhibitory influences, astrocytes and the formation of barriers, glial proteoglycans as axon barriers, and astrocytes and central nervous system regeneration.

Keywords: astrocytes; axon guidance; central nervous system regeneration; glial proteoglycans; axon barriers

Chapter.  5994 words. 

Subjects: Neuroscience

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