Chapter

Transplantation of Schwann cells into the CNS: potential for repair of tract lesions

G. Raisman

in Glial Cell Development

Published in print November 1997 | ISBN: 9781872748542
Published online March 2012 | e-ISBN: 9780191724367 | DOI: http://dx.doi.org/10.1093/acprof:oso/9781872748542.003.0012

Series: The Molecular and Cellular Neurobiology Series

Transplantation of Schwann cells into the CNS: potential for repair of tract lesions

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An important goal in central nervous system (CNS) research is the search for a method to repair traumatic CNS injuries. In adult white matter tracts, cut axons are unable to regenerate beyond the injury site. In the neuropil of adult gray matter, however, it has been shown that new synapses can form and reinnervate denervated postsynaptic sites after injury or after transplantation of embryonic tissue. This suggests that the failure of regeneration after axotomy is due to an inability of the cut axons to regenerate along their original pathways. A number of laboratories have attempted to bridge the failure of regeneration in white matter by transplantation of segments of peripheral nerve or Schwann cells. This chapter provides some examples of studies on the structure of adult central white matter tracts, their ability to support growth of immature axons, and the effects of transplanting Schwann cells into them.

Keywords: central nervous system; white matter tracts; immature axons; Schwann cell transplant; gray matter; peripheral nerve cells

Chapter.  2308 words.  Illustrated.

Subjects: Neuroscience

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