Chapter

Leukocyte migration into the central nervous system

Linda J. Lawson

in Immune Responses in the Nervous System

Published in print November 1997 | ISBN: 9781872748795
Published online March 2012 | e-ISBN: 9780191724381 | DOI: http://dx.doi.org/10.1093/acprof:oso/9781872748795.003.0002

Series: Molecular and Cellular Neurobiology Series

Leukocyte migration into the central nervous system

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The entry of leukocytes into tissue is a fundamental process in the host's response to injury or infection. Limitations on the entry of leukocytes into the central nervous system are one aspect of the ‘immunological privilege’ of the brain. In both the normal and injured brain, leukocyte recruitment is more restricted than under similar conditions in non-CNS tissues. Discovering how the CNS regulates leukocyte recruitment would broaden our understanding of the role of the tissue microenvironment in modulating inflammatory and immune responses. This chapter discusses the study of leukocyte migration into the brain, mononuclear phagocytes, the inflamed brain, lymphocytes, and the problems of entering the brain.

Keywords: leukocytes; central nervous system; immunological privilege; normal brain; injured brain; mononuclear phagocytes; lymphocytes

Chapter.  15350 words.  Illustrated.

Subjects: Neuroscience

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