The role of glial cells in immune responses in the brain

Jochen Gehrmann and Richard B. Banati

in Immune Responses in the Nervous System

Published in print November 1997 | ISBN: 9781872748795
Published online March 2012 | e-ISBN: 9780191724381 | DOI:

Series: Molecular and Cellular Neurobiology Series

The role of glial cells in immune responses in the brain

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Immune reactions in the brain are largely controlled by the interaction between extrinsic immuneffector cells such as T and B cells, and resident glial cell populations. T and B lymphocytes recruited from peripheral immune organs constitute the main extrinsic effector cells, while microglia and astrocytes become rapidly activated as part of an intrinsic immune defence of the brain against such an immune injury. Pathophysiologically important, myelinforming oligodendrocytes are particularly vulnerable during central nervous system (CNS) immune injury. In demyelinating diseases, like multiple sclerosis, injury to oligodendrocytes as well as to components of the CNS myelin sheath plays an important role. This chapter focuses on the involvement of these different cell types during autoimmune injury, with a particular emphasis on intercellular communication between activated glial cells and lymphocytes via cytokines and other mediators.

Keywords: immune reactions; autoimmune injury; intercellular communication; glial cells; lymphocytes; cytokines; central nervous system

Chapter.  7122 words.  Illustrated.

Subjects: Neuroscience

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