Chapter

Neurotrophins: aspects of their <i>in vivo</i> action and physiology

Michael Meyer

in Immune Responses in the Nervous System

Published in print November 1997 | ISBN: 9781872748795
Published online March 2012 | e-ISBN: 9780191724381 | DOI: http://dx.doi.org/10.1093/acprof:oso/9781872748795.003.0005

Series: Molecular and Cellular Neurobiology Series

Neurotrophins: aspects of their in vivo action and physiology

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This chapter discusses selected aspects of the biology of neurotrophins in the context of three major questions. First, what methods are available today to study the physiology of neurotrophins and how do they compare with methods used previously? Second, what do we learn from discrepancies between the in vitro and in vivo actions of neurotrophins? Third, what is the lesson from discrepancies between the effects of neurotrophins observed in pathophysiological situations as compared with physiological contexts? Null mutations of genes encoding neurotrophins (with the exception of NT-4 and p75) and their receptors in mice severely compromise postnatal development, demonstrating that lack of these pathways cannot be fully compensated for. These results demonstrate that, although neurotrophin signalling is essential for the existence of this species, redundant safety mechanisms have not been introduced during evolution.

Keywords: neurotrophins; physiology; postnatal development; neurotrophin signalling

Chapter.  8164 words. 

Subjects: Neuroscience

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