Chapter

Immune responses in the central nervous system in inflammatory demyelinating disease

M. L. Cuzner and T. Smith

in Immune Responses in the Nervous System

Published in print November 1997 | ISBN: 9781872748795
Published online March 2012 | e-ISBN: 9780191724381 | DOI: http://dx.doi.org/10.1093/acprof:oso/9781872748795.003.0006

Series: Molecular and Cellular Neurobiology Series

Immune responses in the central nervous system in inflammatory demyelinating disease

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Detailed immunocytochemical studies of the inflammatory lesion in post-mortem brain from acute cases of multiple sclerosis (MS) reinforce the growing conviction that the immune reaction can be fuelled from within the central nervous system (CNS), although the kinetics of lymphocyte traffic between the blood and cerebrospinal fluid suggest ready access to the CNS compartment for activated T cells. Thus, the persistence of an immune stimulus and the intermittent reactivation of the immune system suggest that MS is a disease of immune regulation, but the nature of its relapsing/remitting course and the exact mechanisms of demyelination are as yet unresolved. This chapter discusses the nature of the cellular infiltrate, humoral immunity in MS, inflammation and demyelination in the CNS in model systems, pathogenetic mechanisms in MS, and regulatory mechanisms in MS.

Keywords: multiple sclerosis; central nervous system; immune reactions; inflammation; demyelination; pathogenetic mechanisms; regulatory mechanisms; immune regulation; activated T cells

Chapter.  12095 words.  Illustrated.

Subjects: Neuroscience

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