Chapter

Central nervous system immune reactions in Alzheimer's disease

Patrick L. McGeer and Edith G. McGeer

in Immune Responses in the Nervous System

Published in print November 1997 | ISBN: 9781872748795
Published online March 2012 | e-ISBN: 9780191724381 | DOI: http://dx.doi.org/10.1093/acprof:oso/9781872748795.003.0007

Series: Molecular and Cellular Neurobiology Series

Central nervous system immune reactions in Alzheimer's disease

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Alzheimer's disease (AD) is a relentlessly progressive dementing disorder with an incidence that increases very sharply with age. Of the many potential bases for neurodegeneration in AD, immune-directed attack is one of the most easily conceived because such processes are inherently destructive. Typically, this destruction is beneficial to the host, as in the warding off of extrinsic pathogens. Sometimes it is not, as in autoimmune diseases. This chapter describes evidence that there is a prominent immune response in AD. Particular attention is given to the autodestructive forces that are inherent to such a response, and the potential harm they can cause. The possibility of ameliorating such damage through the use of anti-inflammatory drugs is discussed.

Keywords: dementia; immune response; autodestruction; neurodegeneration

Chapter.  5160 words.  Illustrated.

Subjects: Neuroscience

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