Chapter

The immunology of brain injury

Maria Cristina Morganti-kossmann and Thomas Kossmann

in Immune Responses in the Nervous System

Published in print November 1997 | ISBN: 9781872748795
Published online March 2012 | e-ISBN: 9780191724381 | DOI: http://dx.doi.org/10.1093/acprof:oso/9781872748795.003.0008

Series: Molecular and Cellular Neurobiology Series

The immunology of brain injury

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The central nervous system (CNS) is regarded as an immunologically privileged site due to its separation from the periphery mediated by the blood-brain barrier. Despite this barrier, immunological reactions can occur within the CNS during disease and injury. Characterization of the cells, mediators and other factors participating in the immunological processes within the brain, as well as the interaction of immune-competent cells of the CNS with the systemic immune system, has been the focus of ongoing research. This chapter reviews the immune functions of glial cells, in particular their ability to produce immune mediators and to interact with their systemic counterparts in pathology and injury of the brain.

Keywords: central nervous system; glial cells; immune functions; immune mediators

Chapter.  12622 words.  Illustrated.

Subjects: Neuroscience

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