Journal Article

Cutaneous Melanin Density of Caucasians Measured by Spectrophotometry and Risk of Malignant Melanoma, Basal Cell Carcinoma, and Squamous Cell Carcinoma of the Skin

Terence Dwyer, Leigh Blizzard, Rosemary Ashbolt, Juliet Plumb, Marianne Berwick and James M. Stankovich

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 155, issue 7, pages 614-621
Published in print April 2002 | ISSN: 0002-9262
Published online April 2002 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/155.7.614
Cutaneous Melanin Density of Caucasians Measured by Spectrophotometry and Risk of Malignant Melanoma, Basal Cell Carcinoma, and Squamous Cell Carcinoma of the Skin

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Recent advances have enabled quite accurate estimation by spectrophotometry of the density of cutaneous melanin. The relation between skin cancers and this objective measure of skin phenotype is examined here. For this purpose, a population-based case-control study of subjects aged 20–59 years of northern European ancestry was conducted in Tasmania, Australia. Cases (n = 244) of cutaneous malignant melanoma during 1998–1999, and a sample of cases of basal cell carcinoma (n = 220) and squamous cell carcinoma (n = 195) of the skin were identified from cancer registrations. Controls (n = 483) were selected from a comprehensive population listing. Melanin at the upper inner arm was estimated from skin reflectance of light of 400 and 420 nm wavelengths. For melanoma, basal cell carcinoma, and squamous cell carcinoma, respectively, the odds ratios comparing the least with the highest of four melanin categories were 6.2 (95% confidence interval (CI): 2.3, 16.6), 6.3 (95% CI: 2.6, 15.1), and 4.2 (95% CI: 1.7, 10.8) for men and 1.9 (95% CI: 1.0, 3.7), 1.4 (95% CI: 0.7, 3.0), and 0.7 (95% CI: 0.3, 1.7) for women. The gender differences were not due to disparities in site of occurrence or (for melanoma) in thickness of the lesion. The authors conclude that, particularly for men, cutaneous melanin density at the upper inner arm is a strong predictor of risk of skin cancer.

Keywords: case-control studies;; melanins;; melanoma;; population;; skin neoplasms; BCC, basal cell carcinoma of the skin;; CI, confidence interval;; CMM, cutaneous malignant melanoma;; ICD-9, International Classification of Diseases, Ninth Revision;; SCC, squamous cell carcinoma

Journal Article.  4559 words.  Illustrated.

Subjects: Public Health and Epidemiology

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