Journal Article

Water, Other Fluids, and Fatal Coronary Heart Disease

Jacqueline Chan, Synnove F. Knutsen, Glen G. Blix, Jerry W. Lee and Gary E. Fraser

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 155, issue 9, pages 827-833
Published in print May 2002 | ISSN: 0002-9262
Published online May 2002 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/155.9.827
Water, Other Fluids, and Fatal Coronary Heart Disease

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Whole blood viscosity, plasma viscosity, hematocrit, and fibrinogen are considered independent risk factors for coronary heart disease and can be elevated by dehydration. The associations between fatal coronary heart disease and intake of water and fluids other than water were examined among the 8,280 male and 12,017 female participants aged 38–100 years who were without heart disease, stroke, or diabetes at baseline in 1976 in the Adventist Health Study, a prospective cohort study. A total of 246 fatal coronary heart disease events occurred during the 6-year follow-up. High daily intakes of water (five or more glasses) compared with low (two or fewer glasses) were associated with a relative risk in men of 0.46 (95% confidence interval (CI): 0.28, 0.75; p trend = 0.001) and, in women, of 0.59 (95% CI: 0.36, 0.97). A high versus low intake of fluids other than water was associated with a relative risk of 2.47 (95% CI: 1.04, 5.88) in women and of 1.46 (95% CI: 0.7, 3.03) in men. All associations remained virtually unchanged in multivariate analysis adjusting for age, smoking, hypertension, body mass index, education, and (in women only) hormone replacement therapy. Fluid intake as a putative coronary heart disease risk factor may deserve further consideration in other populations or using other study designs.

Keywords: blood viscosity; coronary disease; dehydration; fluids and secretions; hemorheology; men; water; women; CI, confidence interval

Journal Article.  4992 words. 

Subjects: Public Health and Epidemiology

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