Journal Article

Fracture Risk in Patients with Celiac Disease, Crohn’s Disease, and Ulcerative Colitis: A Nationwide Follow-up Study of 16,416 Patients in Denmark

Peter Vestergaard and Leif Mosekilde

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 156, issue 1, pages 1-10
Published in print July 2002 | ISSN: 0002-9262
Published online July 2002 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwf007
Fracture Risk in Patients with Celiac Disease, Crohn’s Disease, and Ulcerative Colitis: A Nationwide Follow-up Study of 16,416 Patients in Denmark

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The authors studied fracture risk among 16,416 Danish patients with bowel disease. All patients diagnosed with celiac disease (n = 1,021), Crohn’s disease (n = 7,072), or ulcerative colitis (n = 8,323) in Denmark between January 1, 1983, and December 31, 1996, were included. Each patient was compared with three age- and gender-matched controls randomly drawn from the background population. No increase in fracture risk could be demonstrated for celiac disease before or after diagnosis. In patients with Crohn’s disease, overall fracture risk was increased both before diagnosis (incidence rate ratio = 1.15, 95% confidence interval (CI): 1.00, 1.32) and after diagnosis (incidence rate ratio = 1.19, 95% CI: 1.06, 1.33). Bowel surgery was associated with a decreased risk of sustaining a fracture before diagnosis (odds ratio = 0.70, 95% CI: 0.54, 0.90) and after diagnosis (hazard ratio = 0.81, 95% CI: 0.67, 0.99). Overall fracture risk was not increased in patients with ulcerative colitis, except for a small increase around the time of diagnosis. Increasing age and having a fracture before diagnosis increased the risk of sustaining a new fracture after diagnosis. Crohn’s disease was associated with a minor increase in overall fracture risk in contrast to ulcerative colitis and celiac disease. The severity of the inflammatory process and the amount of corticosteroids given may explain the difference in fracture risk.

Keywords: celiac disease; colitis, ulcerative; Crohn disease; fractures; inflammatory bowel diseases; Abbreviations: CI, confidence interval; ICD, International Classification of Diseases; IRR, incidence rate ratio.

Journal Article.  6064 words.  Illustrated.

Subjects: Public Health and Epidemiology

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