Journal Article

Factors Associated with Oxidative Stress in Human Populations

Gladys Block, Marion Dietrich, Edward P. Norkus, Jason D. Morrow, Mark Hudes, Bette Caan and Lester Packer

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 156, issue 3, pages 274-285
Published in print August 2002 | ISSN: 0002-9262
Published online August 2002 | e-ISSN: 1476-6256 | DOI:
Factors Associated with Oxidative Stress in Human Populations

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Oxidation of biomolecules may play a role in susceptibility to a number of diseases. However, there are few large-scale survey data describing oxidative damage that occurs in humans and the demographic, physical, or nutritional factors that may be associated with it. Such information is essential for the design and analysis of studies investigating the role of oxidative stress in health and disease. This paper presents data on levels of two biomarkers of lipid peroxidation, malondialdehyde and F2-isoprostanes, in 298 healthy adults aged 19–78 years. The study was conducted in Berkeley and Oakland, California, in 1998–1999. Sex was the strongest predictor of lipid peroxidation as measured by both biomarkers (p < 0.0001); it was stronger than smoking. C-reactive protein was positively associated with lipid peroxidation (p = 0.004), as was plasma cholesterol. Plasma ascorbic acid had a strong inverse relation (p < 0.001) with both biomarkers. Plasma β-carotene was also associated with F2-isoprostanes. Other plasma antioxidants were not associated with lipid peroxidation biomarkers, once ascorbic acid was included in the multivariate model. Future surveys and epidemiologic studies should measure at least one marker of oxidative damage, as well as plasma ascorbic acid. These data would permit a better understanding of the role that oxidants and antioxidants play in the health of human populations. Am J Epidemiol 2002;156:274–85.

Keywords: ascorbic acid; biological markers; C-reactive protein; epidemiology, molecular; lipid peroxidation; obesity; oxidative stress; sex characteristics; Abbreviations: Iso-P, F2-isoprostane(s); MDA, malondialdehyde; TBARS, thiobarbituric acid reactive substances.

Journal Article.  8257 words. 

Subjects: Public Health and Epidemiology

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