Journal Article

<b>Serum Insulin and Glucose Levels and Breast Cancer Incidence</b>

Pamela J. Mink, Eyal Shahar, Wayne D. Rosamond, Anthony J. Alberg and Aaron R. Folsom

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 156, issue 4, pages 349-352
Published in print August 2002 | ISSN: 0002-9262
Published online August 2002 | e-ISSN: 1476-6256 | DOI:

          Serum Insulin and Glucose Levels and Breast Cancer Incidence

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The authors examined the association of breast cancer incidence with serum levels of insulin and glucose in a cohort of 7,894 women aged 45–64 years from four US communities. Anthropometric factors and fasting levels of insulin and glucose were measured at baseline (1987–1989). Over an average follow-up period of 7.1 years (1987–1995), 187 breast cancer cases were ascertained. Breast cancer was associated positively with body mass index but not with waist:hip ratio or serum insulin level. After adjustment for age, race, and study site, the incidence of breast cancer was 60% higher among diabetic women than among women with fasting glucose levels under 100 mg/dl, but this association was attenuated after further adjustment for body mass index and other covariates (adjusted rate ratio = 1.39, 95% confidence interval: 0.86, 2.23). Circulating insulin levels were not predictive of future breast cancer incidence, but there may be a weak association with type 2 diabetes, perhaps modulated via increased adiposity.

Keywords: breast neoplasms; glucose; insulin; Abbreviation: ARIC, Atherosclerosis Risk in Communities.

Journal Article.  2530 words. 

Subjects: Public Health and Epidemiology

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