Journal Article

Carotid Wall Thickness and Years Since Bilateral Oophorectomy

Kathleen M. Dwyer, Cheryl K. Nordstrom, C. Noel Bairey Merz and James H. Dwyer

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 156, issue 5, pages 438-444
Published in print September 2002 | ISSN: 0002-9262
Published online September 2002 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwf051
Carotid Wall Thickness and Years Since Bilateral Oophorectomy

Show Summary Details

Preview

Evidence that coronary heart disease risk increases with surgical menopause is consistent. However, findings concerning atherosclerosis and surgical menopause are inconsistent. The Los Angeles Atherosclerosis Study (1995–1996) assessed the cross-sectional relation at baseline between years since bilateral oophorectomy and common carotid artery intima-media thickness (IMT). Participants included 269 employed California women asymptomatic for cardiovascular disease and aged 45–60 years. Ninety-seven women reported a hysterectomy: 42 without oophorectomy or a unilateral oophorectomy and 55 with a concurrent bilateral oophorectomy. IMT was measured bilaterally with B-mode ultrasound and was regressed on age, height, and years since hysterectomy in each group. Among women who had undergone bilateral oophorectomy, IMT was significantly related to years since hysterectomy (β = 0.042 (standard error, 0.018) mm/10 years, p = 0.02). However, IMT was unrelated to years since hysterectomy in the no bilateral oophorectomy group (β = 0.005 (standard error, 0.023) mm/10 years, p = 0.82). Adjustment for high density lipoprotein or low density lipoprotein cholesterol attenuated the association between IMT and years since hysterectomy by about a fourth in the bilateral oophorectomy group. Since over 90% of this group had a history of hormone replacement therapy use, the finding that years since bilateral oophorectomy was associated with increasing atherosclerosis conflicts with a well-known finding that such therapy reverses the adverse effect of bilateral oophorectomy on coronary heart disease.

Keywords: atherosclerosis; cardiovascular diseases; carotid arteries; hysterectomy; ovariectomy; Abbreviations: ARIC, Atherosclerosis Risk in Communities; HRT, hormone replacement therapy; IMT, intima-media thickness; SE, standard error.

Journal Article.  4366 words.  Illustrated.

Subjects: Public Health and Epidemiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.