Journal Article

Risk of Breast Cancer Classified by Joint Estrogen Receptor and Progesterone Receptor Status among Women 20–44 Years of Age

Julie A. Britton, Marilie D. Gammon, Janet B. Schoenberg, Janet L. Stanford, Ralph J. Coates, Christine A. Swanson, Nancy Potischman, Kathleen E. Malone, Donna J. Brogan, Janet R. Daling and Louise A. Brinton

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 156, issue 6, pages 507-516
Published in print September 2002 | ISSN: 0002-9262
Published online September 2002 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwf065
Risk of Breast Cancer Classified by Joint Estrogen Receptor and Progesterone Receptor Status among Women 20–44 Years of Age

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To gain insight into whether breast cancer tumors jointly classified by estrogen receptor (ER) and progesterone receptor (PR) status represent diseases with differing etiologies, data from a population-based case-control study of US women 20–44 years of age were analyzed. Cases included 1,556 women diagnosed between 1990 and 1992. Age- and geographic-frequency-matched controls included 1,397 women identified by random digit dialing. Heterogeneity between ER+PR+ and ER–PR– tumors was most pronounced in relation to age, race, and recreational exercise at 12–13 years of age. Multivariate-adjusted odds ratios for ER+PR+ tumors were 0.64 (95% confidence interval (CI): 0.47, 0.89) for 30–34 versus 40–44 years of age, 0.89 (95% CI: 0.63, 1.25) for Black versus White race, and 0.84 (95% CI: 0.68, 1.03) for exercise at 12–13 years of age above versus at or below the median. Corresponding odds ratios for ER–PR– tumors were 1.24 (95% CI: 0.86, 1.77), 1.51 (95% CI: 1.07, 2.14), and 1.15 (95% CI: 0.90, 1.48). Risk of ER–PR– cancer in relation to menstrual and reproductive (parity and lactation) characteristics, alcohol consumption, and family history of breast cancer was similar to that observed for ER+PR+ tumors. These findings only modestly support the hypothesis that hormonally related risk factors have differing relations with ER+PR+ versus ER–PR– tumors among younger women.

Keywords: breast neoplasms; case-control studies; receptors, estrogen; receptors, progesterone; risk factors; Abbreviations: BMI, body mass index; CI, confidence interval; ER, estrogen receptor; PR, progesterone receptor; WHR, waist-to-hip ratio.

Journal Article.  6732 words. 

Subjects: Public Health and Epidemiology

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