Journal Article

Anthropometric Characteristics, Physical Activity, and Risk of Non-Hodgkin’s Lymphoma Subtypes and B-Cell Chronic Lymphocytic Leukemia: A Prospective Study

James R. Cerhan, Carol A. Janney, Celine M. Vachon, Thomas M. Habermann, Neil E. Kay, John D. Potter, Thomas A. Sellers and Aaron R. Folsom

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 156, issue 6, pages 527-535
Published in print September 2002 | ISSN: 0002-9262
Published online September 2002 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwf082
Anthropometric Characteristics, Physical Activity, and Risk of Non-Hodgkin’s Lymphoma Subtypes and B-Cell Chronic Lymphocytic Leukemia: A Prospective Study

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Anthropometric characteristics, physical activity, and risk of non-Hodgkin’s lymphoma, its subtypes, and B-cell chronic lymphocytic leukemia (B-CLL) were evaluated in a prospective cohort study of 37,931 Iowa women who were aged 55–69 years at baseline in 1986. Through 1998, 261 cases of non-Hodgkin’s lymphoma (137 diffuse, 58 follicular, and 32 small lymphocytic lymphomas) and 63 cases of B-CLL were identified by linkage to the Iowa Cancer Registry. Height, weight, body mass index, waist/hip ratio, and physical activity were not associated with risk of non-Hodgkin’s lymphoma overall or with diffuse or follicular lymphoma in particular. After adjustment for other non-Hodgkin’s lymphoma risk factors, there was an inverse association of baseline body mass index (relative risks (RRs) across quartiles: 1, 0.4, 0.4, 0.3; p trend = 0.03) with risk of small lymphocytic lymphoma. In contrast, for B-CLL there were suggestive positive associations with body mass index at age 50 years (RRs across quartiles: 1, 1.9, 1.5, 2.7; p trend = 0.03) and (more weakly) baseline body mass index (RRs across quartiles: 1, 1.1, 1.6, 1.3; p trend = 0.3). In summary, we found no evidence that height, weight, body mass, or physical activity plays an important role in non-Hodgkin’s lymphoma overall or in diffuse or follicular lymphoma in particular. The opposite associations of body mass index with small lymphocytic lymphoma versus B-CLL may be a chance finding but, if confirmed, would suggest different etiologies for these malignancies.

Keywords: anthropometry; cohort studies; leukemia, lymphocytic, chronic; lymphoma, non-Hodgkin; Abbreviations: B-CLL, B-cell chronic lymphocytic leukemia; CI, confidence interval; ICD-O-2, International Classification of Diseases for Oncology, Second Edition; RR, relative risk.

Journal Article.  6473 words. 

Subjects: Public Health and Epidemiology

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