Journal Article

Preterm Birth and Licorice Consumption during Pregnancy

Timo E. Strandberg, Sture Andersson, Anna-Liisa Järvenpää and Paul M. McKeigue

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 156, issue 9, pages 803-805
Published in print November 2002 | ISSN: 0002-9262
Published online November 2002 | e-ISSN: 1476-6256 | DOI:
Preterm Birth and Licorice Consumption during Pregnancy

More Like This

Show all results sharing this subject:

  • Public Health and Epidemiology


Show Summary Details


Heavy licorice (glycyrrhizin) consumption has been associated with shorter gestation. The aim of the present study was to test whether this association also applies to preterm (<37 weeks) births. In 2000–2001, a sample of 95 Finnish women who delivered preterm singletons was compared with controls (n = 107) who delivered babies of normal gestational age in the same hospital. Glycyrrhizin intake was calculated from questionnaires containing detailed items on licorice consumption. Glycyrrhizin exposure was grouped into three levels: low (<250 mg/week), moderate (250–499 mg/week), and heavy (≥500 mg/week). Heavy consumption versus a lower level of consumption was associated with a more than twofold increased risk of preterm (<37 weeks) delivery. The association was stronger when only the 40 births classified as early preterm delivery (<34 weeks) were included (odds ratio = 3.07, 95% confidence interval: 1.17, 8.05 for the fully adjusted model). In conclusion, heavy glycyrrhizin exposure was associated with preterm delivery and may be a novel marker of this condition.

Keywords: gestational age; glycyrrhizic acid; pregnancy; Abbreviation: SD, standard deviation.

Journal Article.  1785 words. 

Subjects: Public Health and Epidemiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.