Journal Article

<i>HLA-DPB1</i> and Chronic Beryllium Disease: A HuGE Review

Erin C. McCanlies, Kathleen Kreiss, Michael Andrew and Ainsley Weston

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 157, issue 5, pages 388-398
Published in print March 2003 | ISSN: 0002-9262
Published online March 2003 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwg001
HLA-DPB1 and Chronic Beryllium Disease: A HuGE Review

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The human leukocyte antigen (HLA) complex is a series of genes located on chromosome 6 that are important in normal immune function. Susceptibility to chronic beryllium disease, a granulomatous lung disease that appears in workers exposed to beryllium, is modified by genetic variants of the HLA-DP subregion. Evaluation of HLA-DPB1 sequence motifs in current and former beryllium workers implicated a glutamic acid residue at position 69 (HLA-DPB1Glu69) in chronic beryllium disease. This finding has since been extended to specific HLA-DPB1Glu69 alleles. Specific job tasks have also been implicated in degree of risk, and in this paper the authors explore gene-environment interaction. The utility of this genetic information for prospective, current, and former beryllium workers must be weighed against the potential for employment and insurance discrimination. Continued research in the beryllium-exposed population will be important for improving personal risk assessment and identifying high-risk genes associated with disease progression.

Keywords: berylliosis; beryllium; chronic beryllium disease; epidemiology; genetic screening; HLA-DP antigens; HLA-DPB1; occupational exposure; Abbreviations: Arg, arginine; Asp, aspartic acid; BHWCD, beryllium hypersensitivity without clinical disease; CBD, chronic beryllium disease; CI, confidence interval; Glu, glutamic acid; HLA, human leukocyte antigen; Lys, lysine; OR, odds ratio; TNF-α, tumor necrosis factor-α.

Journal Article.  7509 words.  Illustrated.

Subjects: Public Health and Epidemiology

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