Journal Article

Exposure to Ambient Fine Particulate Matter and Primary Cardiac Arrest among Persons With and Without Clinically Recognized Heart Disease

J. Sullivan, N. Ishikawa, L. Sheppard, D. Siscovick, H. Checkoway and J. Kaufman

in American Journal of Epidemiology

Published on behalf of Johns Hopkins Bloomberg School of Public Health

Volume 157, issue 6, pages 501-509
Published in print March 2003 | ISSN: 0002-9262
Published online March 2003 | e-ISSN: 1476-6256 | DOI: http://dx.doi.org/10.1093/aje/kwg015
Exposure to Ambient Fine Particulate Matter and Primary Cardiac Arrest among Persons With and Without Clinically Recognized Heart Disease

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The authors studied the association between incidence of primary cardiac arrest and daily measures of fine particulate matter (≤2.5 µm) using a case-crossover study of 1,206 Washington State out-of-hospital cardiac arrests (1985–1994) among persons with (n = 774) and without (n = 432) clinically recognized heart disease. The authors compared particulate matter levels on the day of the cardiac event and the 2 days preceding the event with levels from matched reference days. The estimated relative risk for a 13.8-µg/m3 increase in fine particulate matter (nephelometry: 0.54 × 10–1 km–1 bsp) on the day prior to cardiac arrest was 0.94 (95% confidence interval: 0.88, 1.02). Pollutant levels measured on the same day as the event and on the 2 days preceding the event demonstrated similar results. No increased risk was found among all cases with preexisting cardiac disease (odds ratio = 0.97, 95% confidence interval: 0.89, 1.07); however, an unexpected association appeared between current smokers with preexisting heart disease and increased particulate matter levels 2 days prior to the event (odds ratio = 1.29, 95% confidence interval: 1.06, 1.55). This association was not present in the 0- or 1-day lag analyses or in persons with other diseases. There was no consistent association between increased levels of fine particulate matter and risk of primary cardiac arrest.

Keywords: air pollutants; air pollution; heart arrest; heart diseases; environmental exposure; Abbreviations: CI, confidence interval; PM1.0, particulate matter ≤1.0 µm in aerodynamic diameter; PM2.5, particulate matter ≤2.5 µm in aerodynamic diameter; PM10, particulate matter ≤10 µm in aerodynamic diameter.

Journal Article.  6040 words. 

Subjects: Public Health and Epidemiology

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